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Poly MVA -

Following is the remainder of the literature that Dr. Goldstein supplied me with. Remember, this was written for humans. Polydox or PolyMVA A trimeric palladium compound with properties of a ucleotide reductase. It is a dark, almost reddish brown liquid. Introduction Polydox is he name given to a novel compound recently patented. The chemical descrtion and some of the chemical properties are described in the patent and will not be reviewed here. Biochemical investigations ow in progress under the direction of Garnett-McKeen may indicate that this compound activates ntracellular receptors. Theoretically, this activation has a minimal or no measurable effect on normal cells but drives to destruction cells with altered (maliginant) genetic changes. Currently, most cancer chemotherapeutics when used in terminal stages diminish the quality of life while providing various degrees of remission. It is believed that POLYDOX may encourage tumor remission with minimal effect or deterioration of quality of life. Description POLYDOX, the United States name, or POLYMVA, a compound with approval for use in Mexico, is a synthetic nucleotide reductase. The inventor, Dr. Merrill Garnettt, discovered that lipoic acid as used in the present formula is highly specific for transferring electron energy from a normal metabolic hydrogen carrier to nucleic acids. The science of molecular biology indicates altered DNA as a principle fctor in malignant development. Altered genes produce abnormal protein substances. A major factor in the success of POLYDOX has been to provide an electron energy transfer mechanism from normal metabolic hydrogen carriers to nucleic acids. Nucleic acids are the main constituent of DNA. POLYDOX induces energy dependat conformational changes in DNA as a result of the reduced state it induces in the nucleotides. It is postulated that ras oncogenesis is related to famesyl transfer. Blocking this transfer allows the normalized transfer of electron charges to occur from the lipid part of the membrane. In addition to its energy transfer properties, POLYDOX is an effective anti-oxidant. Cancerous cells, cells wtih altered DNA, are characterized as unable to produce adequate wter as a product of normal metabolism. POLYDOX stimulates the production of intracellular water, thus driving the cell toward normalcy. Indications POLYDOX is indicated n conditions of abnormal rapid cell division. Extensive (over three years) use by Dr. Falk, oncologist of Canada, found no effect on the normally rapidly dividing cells such as hair, lung, ntestne, or marrow cells. Patients with abnormally dividing cells were in many cases benefitted. Non-malignant Uses Anecdotal reoprts indicate unusual success in the treatment of non-malignant conditions such as fibromatosis, psoriasis, Alxheimer's disease, and multiple sclerosis. POLODOX is also efective in the treatment of herpes, strokes, and hepatitis. There is a demonstrated tonic effect which has een widely reported especially in older patients who suffer from fatigue and loss of appetite. This tonic effect of increased energy is postulated to be caused by the activation of B12 and thiamin molecules whose effect has been potentiated by the configuration of the new molecule. This report will not discuss the many functions and uses of these vitamins except to say that they seem to be more active in POLYDOX form. It is possible that some of the beneficial neurological changes reported n multiple sclerosis, central nervous system malignant tumors, and Alzheimer's are due to the active vitamns contaned in POLYDOX. There is some evidence that palladium may be an essential trace metal. It appears that palladium has an effect on the structure of certan bioinorganics and thus changes their function. Further research is being done by Metals in Medicine and the work of R. Lampeka of Department of Chemistry, Kiev University and H. Wanjek of the Institute of Inorganic Chemistry, Munich University. Uses in Malignant Conditions POLYDOX was invented with the purpose of finding a non-toxic treatment of cancer. The altered gene was nown as the proximate cause of malignant transformations. The ucleotides were identified as the b asic olecular structures which controlled cell division and replication. Enzymes were known to effet DNA repair and thus Dr. M. Garnett focused his research on nucleotide reductases with the result of the development of POLYDOX. The concept of repairing the altered gene as a treatment for cancer by using semisynthetic compound is a major departure from the current concept of destruction. The most dramatic responses were noted with BRAIN TUMORS. Rapid success has been documented in cases of Glioblastomas. Even in the late stages with extensive symptoms of partial paralysis, memory changes, and ambulatory abnormalities, there was a quick return to normal functions. Lung cancers, especially bronchogenic carcinomas, are notoriously difficult to treat. POLYDOX use has substantially increased life span. Excess pleural fluid is a complication, but can be reduced by reducing the dose of POLYDOX. Ovarian cancers respond well to oral use of POLYDOX. Long term success in this cancer and others is related to long term use of POLYDOX. Breast cancers, whether they are hormone sensitive or not, seem to respond to POLYDOX. Late stages with extensive bone metastasis have reported resolution of the bone loss and reduction of pain. Megace, an antiestrogen, augments the benefit. Symptom Relief Any cancer patient who has suffered pain, anorexia or weight loss may benefit from a 30 day trial. Most cancer patients report improved appetite and weight gan within the first few days of beginning POLYDOX. The question of how POLYDOX erduces pain in cancer requires more invetigation. One theory suggest that as the tumor cells are destroyed, the smaller mass reduces pressure caused pain. As an Adjuvant The original work on humans in Canada proved that POLYDOX was very safe. In over two years of use, it produced no reactions. Its main use was an adjuvant. It was used in Canada by an oncologist, Dr. Falk As an Adjuvant The original work on humans in Canada proved that POLYDOX was very safe. In over two years of use, it produced no reactions. Its main use was an adjuvant. It was used in Canada by an oncologist, Dr. Falk, usually in conduction with standard chemotherapy. He reported benefits using this combination in the majority of patients. The benefits he reported included pain reduction or pain control, increased energy, improved appetite and weight gain. Some patients are still using low doses of POLYDOX and have no apparent signs of cancer after two or three years of use. Radiotherapy The strong antioxidant effects of POLYDOX are probably responsible for the increased benefit of radiation treatments. It is postulated that (1) POLYDOX protects surrounding tissues, thereby causing less postirradiation damage (2) POLYDOX sensitizes the malignant cell, making it more responsive to lower doses of malignant cell, making it more responsive to lower doses of radiation. These effects require more controlled studies. TOXICITY STUDIES Animal studies and the studies in Canada prove the very safe nature of POLYDOX. Toxicity studies were performed which et the standards of the FDA. They proved there was no toxicity in the doses tested. Extensive intravenous and oral toxicity studies by testing agent Pharmakon USA, PO Box 600, Waverly, PA, reported: "Based upon the results from the Acute Intravenous Toxicity Study in mice, the test article synthetic Reductase 25mg/ml is considered to be non-toxic when administered as an intravenous injection of 15.0 ml/kg." "Based upon the results from the Acute Oral Toxicity Study in Mice (14 day), the estimated acute oral LD50 for combined sexes for the Synthetic Reductase (25mg/ml) is determined to be greater than 5000 mg/kg." Mitogen tests are routinely performed by using Ames/Salmonella Assay. "The results of synthetic DNA reductase were negative." There is also a To Whom it May Concern letter dated May 1998 from a NYC vet who was treating a 10 yr. old neutered male Siamese who was diagnosed with lymposarcoma, soft tissue on bridge of nose. The owner decided instead of conventional therapies to treat the cat solely with POLYMVA. After two months of oral POLYMVA the cat has no visible mass on his nose. Marla Country & Kiska

 Dear Bobby,

We got ours directly from Poly distributor. The
contact person is Tim Maston 1-800-960-6760,

Advanced Medical Research Center
539 Telegraph Cny Rd PMB 281
Chula Vista CA 91910

The site to go is the poly survivor's URL. AMRC do
give out free bottle of Clodronate (sp)/Bonefos for
free with Poly order if requesed. The price is pretty
standardlized nowadays. $360 per 240 cc. That lasts 10
days in Dago's case (he weighed 50 lbs then). When buy
10 at once, they drop to $330 per bottle.

There are other souces that may be cheaper, such as
from Mexico, but the chance of conterfeit is not worth
the risk. My only caution advice to any protential
users is to adhere to the recommended dosage to get
Poly's benefit. Because this product is so "young",
the makers and users are in experimental state, the
dose changed from the product's inception of 4 cc per
day for doggies to body weight dependancy.

There is a live doggie case on Poly discussion group
in yahoo. Benson has brain tumor and Poly shrunk the
tumor 15% (?) in 25 days.