study showing that
findings suggest that ovariohysterectomy when mammary tumours are removed does not have a significant effect on
the progression of malignant disease, and that about one in four bitches with a benign mammary tumour is likely to develop a further
tumour in another gland.
Feline Mammary Tumors
- malignancies in cats
" Cats with tumors > cm im diameter
have a median survival of 6 months, whereas cats with tumors < 2 in diameter have a median survival of approximately 4 years.
The role of chemotherapy from MGT is unknown in cats, but because of the aggressive nature of feline MGT, it may prove to
be beneficial." - J Vet Intern Med 2003 Jan-Feb;17(1):102-6
:
Influence of host factors on survival in dogs with malignant
mammary gland tumors.
Philibert JC, Snyder PW, Glickman N, Glickman LT, Knapp DW, Waters DJ.
Department of Veterinary Clinical Sciences, Purdue University School of Veterinary
Medicine, West Lafayette, IN, USA.
jphilibert@nevog.com
The purpose of our study was to determine if specific host factors, such as age at
diagnosis, obesity, and hormone status, influence the prognosis of canine mammary
gland carcinomas and to confirm if previously reported risk factors (ie, histologic
subtype, tumor size, and World Health Organization [WHO] stage) were important
in a large series of affected dogs. Ninety-nine female dogs with mammary gland
carcinomas, no previous therapy, an excisional biopsy, and known cause of death
were studied. No significant association with survival was noted for age at diagnosis
(chronologic or physiologic), obesity, or hormone status (ie, spayed versus intact,
regardless of time of being spayed). Of the tumor factors analyzed, the histologic
subtype anaplastic carcinoma (P = .02), WHO stage I (P = .01), evidence of
metastasis at the time of diagnosis (P = .004), and tumor size of 3 cm or smaller (P =
.005) all significantly influenced survival. Dogs that were classified as having
tumor-related mortality had a shorter postoperative survival compared to dogs that
died of other causes (14 months versus 23 months; P = .03). In conclusion, histologic
subtype, WHO stage, and tumor size remain important prognostic factors in canine
mammary gland tumors. Further study of other prognostic factors is needed to
determine which tumors are adequately addressed with local therapy only and which
dogs may require adjuvant treatment with chemotherapy. - great references to melatonin from Life extension
- probably next best discussion(who knows if it is biased)re melatonin and breast cancer
appears to come from Thorne's research
notice says nontoxic in humans at high doses..there apppears no FDA documentation re requirements-also notice re anti oxidant and possible IBD
". Anticancer. Studies show that Melatonin deficiency may be a cause of breast and
prostate cancer or at least a guard against it. Melatonin prevents breast cancer cell
division in estrogen-dependent and non-estrogen dependent cancers. In fact, one
study showed that the reason meditation is beneficial in cancer therapy is that it
boosts Melatonin production. Another study showed that Melatonin amplifies the
immune effects of Interleukin-2 and protects against chemotherapy toxicity and
radiation. 30 days of 10 mg per night Melatonin in solid tumor patients boosted their
levels of tumor necrosis factor (TNF) by 28%, gamma interferon by 51% and
Interleukin-2 by 41%, a radical increase. In fact, the prescription drug,
Neupogen™, given to cancer and AIDS patients to stimulate their immune systems
works by stimulating Melatonin secretion but it costs thousands of dollars. Melatonin
rhythmicity (nightly secretion) is suppressed in cancer patients. Melatonin also
counteracts the atrophy of the thymus gland, the master immune system gland" - here some research links for melatonin and human breast cancer
- huge compilation of melatonin abstracts
- yet another review of melatonin literature
- university of Penn.August 2001-mammary tumorsan overview-third most common cancer in cats-almost 90 percent tumors are malignant-most effective treatment to date-"surgical incisive"-if benign-still helpful measure for prevention-" It is unclear whether spaying a cat early in life
diminishes the risk for development of mammary cancer later on." Spaying at the time of mammary tumor resection has no measurable effect on
the rate of tumor reoccurrence."
- mammary tumors..maxshouse
- Feline Mammary Adenocarcinoma (FMGAC)Dr. Alice Villalobos
Rarely one will see a young, intact female cat with huge mammary masses
which are benign. This condition is known as fibroepithelial hyperplasia and should not be mistaken
for FMGAC.
- mammary-vetinfo-dogs
- cats=vetinfo
- mammary tumors..vrcc
- summary of conference on melatonin, cancer, EMF but for humans
- canine mammary tumors u of penn "Breeds at risk for developing mammary gland tumors
include toy and miniature Poodles, Spaniels, and German Shepherds." The
average age of dogs at diagnosis is 10-11 years. "Studies have shown that spaying a dog before her first, second, or third heat
cycle can significantly decrease the risk for developing mammary gland tumors
later in life.
"Half of all mammary
gland tumors are benign and can be treated successfully with surgery alone.
- histovet-feline and canine mammary tumors-the vet makes gives "Ninety-to-ninety five percent of all canine mammary neoplasia is behaviorally benign. "-very interesting read..also with implications for human breast cancer maybe
- Effects of bitter melon (Momordica charantia l.) or ginger
rhizome (Zingiber offifinale rosc) on spontaneous mammary
tumorigenesis in SHN mice.
The effects of chronic treatment with hot water extract of Bitter Melon
(Momordica charantia L.) or Ginger Rhizome (Zingiber offifinale Rosc) on
spontaneous mammary tumorigenesis were examined in SHN virgin mice. In mice
given free access to extract of Bitter Melon (0.5%) or Ginger (0.125%) in
drinking water, the development of mammary tumors was significantly inhibited.
Furthermore, the former inhibited uterine adenomyosis with a common
pathological background to mammary tumors and the latterinhibited mammary
tumor growth. While the mechanism of the effects of these natural products
remains to be clarified, there were no adverse effects of chronic treatment
with these agents as estimated from body weight, food and water intake and
various plasma component levels as well as external appearance. Thus, these
natural products, popular in Japan as foodstuffs, also appear to have a health
benefit.
- Progestin-induced mammary growth hormone (GH) production.
"
Toxicity studies using beagle dogs revealed in the 1980s that synthetic progestins may induce a
syndrome of growth hormone (GH) excess, known as acromegaly, and the development of
predominantly benign mammary hyperplasia."
for instance ovaban and megace acetate are synthetic progestins-some recommend using it for cat who sprays. Also for an eye condition,eosinophilic keratitis, Ovaban is recommended.
- Polyunsaturated fatty acids
"Mammary cancer is the second leading cause of cancer death in women, the second most common
neoplasm in dogs and the third leading neoplasm in cats. Mammary tumors are similar in
morphology and progression in these species, so cats and dogs are good models for determining
treatment or prevention modalities for the human population. Epidemiological, in vitro and rodent
studies have demonstrated that polyunsaturated fatty acids (PUFA) can influence the growth,
progression and metastasis of mammary cancer"
link to small write up on Pufa Omega 6..flaxseed has mostly omega 3s so possibly ups the ratio to the Omega 3 side
Re lactic acid and possible cancer fighting properties-plus raw versus cooked vegetablesI was given permission by Suze F.to post it here
Hi Toni,
I'd love to hear what you come up with on your Internet search. Here is a
quote from CJ Puotinen's "The Encyclopedia of Natural Pet Care,
"In his book "How to Fight Cancer and Win," William L. Fischer describes the
importance of saurkraut and other lactic acid fermented foods as a support
therapy in human cancer prevention and treatment. Those are fresh, raw,
unpasteurized natural pickels, made without vinegar and with a minimum of
salt, which are, Fischer explained, an excellent bowel tonic; they improve
digestion, which in cancer patients is often compromised by a lack of
hydrochloric acid and enzymes, and are themselves rich in easily assimilated
nutrients. Lactic acid maintains beneficial intestinal flora while helping
to eliminate harmful bacteria. According to German physician and scientist
Johannes Kuhl, M.D., Ph.D., lactic acid foods are "hostile" to cancer. "No
other full-value diet will do the job [of reducing cancer cases]," he
wrote."
It sounds like this process may more closely replicate the "pre-digested"
plant material in a prey's stomach and intestines than cooked veggies, as
you mentioned. However, I disagree that wolves and or dogs' ancestors didn't
eat raw plant materials albeit, I believe, in small amounts. No one seems to
agree how much raw plant material they ate but they ate some as do many
modern day dogs if the owner allows it. Juliette de Bairacli Levy writes in
"The Complete Herbal Handbook For the Dog and Cat," "The dog is no true
vegetable eater, taking only what it gets from the contents of the
intestines of the prey which it kills, and in very limited amounts, direct
from various grasses, berries and mosses, which it seeks out for itself.
Many dogs have completely lost their instinct for the seeking-out of herbs;
only for that admirable, intestinal cleansing herb, couch grass (Agropyrum
repens) , do dogs seem to retain their herb eating instinct..." (p.32) She
does emphasize that dogs seek herbs more for medicinal purposes than for
nutritional ones.
Maybe we don't really differ on this point, I just think they do eat some
raw plant material although a very small ratio compared to meat consumption.
I do agree that dogs' ancestors probably didn't eat much raw cabbage or
turnip unless these agriculturally-raised veggies have wild counterparts
somewhere in the world where dogs' ancestors lived. Hmmm.... I'm beginning
to think I overfeed veggies....I give my two 10 lb. dogs about 3 Tbs. each
per day. Sometimes a little more, sometimes a little less. This is another
issue I've been pondering along with the digestion issue....